Antimicrobial Defense Linked to the Hemostatic Response
This article at a glance
- This study reports that the coagulation of blood leads to the formation of arachidonic acid (AA)-, eicosapentaenoic acid (EPA)- and docosahexaenoic acid (DHA)-derived specialized proresolving mediators (SPMs) that promote microbial clearance.
- Clotting of human whole blood led to the formation of a distinct cluster of SPMs, namely lipoxin B4, resolvin E1, resolvin D1, resolvin D5, and maresin 1.
- The results uncover a new role of hemostasis that extends beyond the current understanding of it as a passive barrier that stems bleeding, to one that involves the innate immune system to actively control the risk of microbial infection.