Gaining Insight into the Relative Contributions of EPA and DHA to Lowering the Risk for Atherothrombotic Disease Incidence
This article at a glance
- Two recent studies have assessed whether either EPA or DHA may be more closely associated to markers of risk for the development and incidence of atherosclerotic disease.
- In elderly Japanese patients at high risk for acute atherothrombotic complications, the serum EPA level was associated with a lower incidence of plaque destabilization and infarction.
- In obese adults 18-70 years old with sub-clinical systemic inflammation, the daily intake of DHA was related to a more marked anti-inflammatory blood profile than EPA intake.
- The studies provide new indications that DHA and EPA may serve different roles to regulate distinct aspects in the temporal development of atherogenesis and acute atherothrombotic coronary disease. Further studies are required to replicate and refine these observations.