The Impact of Omega-3 LCPUFA on Colorectal Cancer Development Guides Clinical Research towards Considering Immune Modulation and Regulation of Genomic Stability
This article at a glance
- In adults that develop colorectal cancer, survival is increased if omega-3 LCPUFA intake is modestly increased after diagnosis.
- Large prospective cohort studies tracked colorectal cancer incidence and assessed genomic stability and immune cell composition of tumors in relation to dietary intake of omega-3 long-chain polyunsaturated fatty acids (omega-3 LCPUFA).
- The risk of developing tumors characterized by higher genomic instability and richer in infiltrates of T-regulatory lymphocyte cells was significantly reduced in people with higher dietary intakes of omega-3 LCPUFA.