Research Summary Archives

This article at a glance In adults that develop colorectal cancer, survival is increased if omega-3 LCPUFA intake is modestly increased after diagnosis. Large prospective cohort studies tracked colorectal cancer incidence and assessed genomic stability and immune cell composition of tumors in r...

This article at a glance A recent study in mice reports that human and mouse secretory group X phospholipase A2 preferentially releases omega-3 long-chain polyunsaturated fatty acids to serve anti-inflammatory and tissue-protective activities in the colon. Selective release of arachidonic acid ...

This article at a glance This study assessed the effect of DHA-derived lipid mediators on IgE formation by B-lymphocytes, an important component of the adaptive immune system that is activated in allergies. The study reports that resolvin D1 inhibits the differentiation of human B-cells...

This article at a glance Two recently published studies report on the relations between dietary intake and levels of poly-unsaturated fatty acids (PUFA) in blood and the acute phase response C-reactive protein (CRP) in older people. In one study, the omega-3 index was negatively associated w...

This article at a glance Three recent studies have looked at different aspects of early post-surgical immune-modulatory effects of perioperative supplementation with EPA/DHA. These include lowered neutrophil activation potential, a decreased neutrophil-to-lymphocyte ratio, and reduced need for...

This article at a glance In two clinical cases, EPA was recognized to possibly offer support to the long-term remission of autoimmune small vessel vasculitis, when used in combination with methylprednisolone and aspirin. The study next addressed the mechanisms whereby this may occur. A potentia...

This article at a glance This study addressed the levels of anti-inflammatory and resolution-promoting lipid mediators derived from EPA and DHA in human plasma during oral supplementation with EPA/DHA over a relatively short period of five days. The potential effect of aspirin on the selective...

The long chain polyunsaturated fatty acids (PUFA) arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are used by the body to produce lipid mediators, which are derivatives with a variety of functions including regulating inflammatory responses, while protecting tissue...

One of the most rapidly advancing areas of immune function research is the elucidation of a variety of anti-inflammatory, pro-resolving mediators derived from long-chain omega-3 PUFAs (n-3 LC-PUFAs), including EPA, DHA and n-3 DPA (docosapentaenoic acid) produced at the site of inflammation. To date...

DHA, the major PUFA in the brain, is required for optimal fetal and infant development of the brain, retina and nervous system and is vital for the healthy functioning of these tissues throughout life. DHA is important in many cell communication pathways, in the ability of neuronal connections to ad...

The incidence of asthma has been increasing worldwide and now affects about 193 million individuals globally. In Denmark, the prevalence of asthma doubled from 5.3% to 11.7% over the period from 1986 to 2001. Recognized as a heterogeneous condition, asthma often follows persistent childhood wheeze. ...

Evidence for a relationship between a mother’s consumption of fish, especially fatty fish, during pregnancy and the risk of her child developing asthma in childhood is inconsistent. Consumption of fish oil during pregnancy was associated with a significantly lower rate of allergic asthma at age 16 y...