Research Summary Archives

  This article at a glance This prospective multi-ethnic cohort study has examined the relationships between various polyunsaturated fatty acids in plasma phospholipids with the development of  atherosclerosis over a 10 year period in adults that were free of cardiovascul...

This article at a glance This study reports that the coagulation of blood leads to the formation of arachidonic acid (AA)-, eicosapentaenoic acid (EPA)- and docosahexaenoic acid (DHA)-derived specialized proresolving mediators (SPMs) that promote microbial clearance. Clotting of human whole blo...

This article at a glance The potential utility of the ratio of resolvin D1 (RvD1), a pro-resolving lipid mediator derived from DHA, to leukotriene B4 (LTB4), a pro-inflammatory mediator derived from AA, in saliva was determined to predict the level of non-resolving vascular inflammation. The st...

  Prof. Dr. C. von Schacky, Preventive Cardiology, Med Clinic I, University of Munich, and Omegametrix, Martinsried, both Germany. Email: Clemens.vonSchacky@med.uni-muenchen.de   Cardiac societies, like the American Heart Association (AHA) or the European Society of Cardiology (ESC), p...

This article at a glance This pilot study evaluated the concept that stratification of study participants can be useful for improving interpretations of the relationship between long-chain polyunsaturated fatty acid (LCPUFA) intake and biological effect. In patients scheduled for coronary ar...

This article at a glance This study addressed the relationship between omega-3 status in the Inuit and the plasma levels of omega-3 LCPUFA-derived isoprostanes. EPA-derived isoprostane levels were positively related to omega-3 fatty acid status, and unrelated to cardiometabolic risk factors...

This article at a glance A thin, pliable, biodegradable multi-layered material incorporating the DHA-derived lipid mediator resolvin D1 (RvD1) was developed. The thin-film device allowed sustained diffusion of RvD1 from the surface with the lowest copolymer density, permitting one-sided release...

In congestive heart failure, the heart is unable to pump sufficient blood for the rest of the body’s needs. The condition can develop as a result of coronary artery disease, high blood pressure, obesity, diabetes or other disorder. About 75% of patients with heart failure have hypertension, with a p...

This article at a glance Two recent studies have assessed whether either EPA or DHA may be more closely associated to markers of risk for the development and incidence of atherosclerotic disease. In elderly Japanese patients at high risk for acute atherothrombotic complications, the serum EPA l...

This article at a glance This is the first prospective cohort study that determined if a relationship between PCB exposure and risk for myocardial infarction exists in men, and if such an association is sensitive to the dietary intake of EPA and DHA. The study reports that PCB exposure is linke...

This article at a glance This study has examined the relationship between ALA and omega-3 LCPUFA intake, and the risk of developing cardiovascular disease and death in older adults. People who were at known risk of developing cardiovascular disease and that met international recommended intake ...

This article at a glance Two recent studies have addressed if dietary supplementation with fish oil or DHA-enriched canola oil would modify the plasma levels of PCSK9, a pivotal regulator of LDL levels. Modest decreases in PCSK9 levels were achieved in both studies, demonstrating that this prot...